THE APOLIPOPROTEIN-E ALLELE EPSILON-4 IS OVERREPRESENTED IN PATIENTS WITH THE LEWY BODY VARIANT OF ALZHEIMERS-DISEASE

被引：135

作者：

GALASKO, D ^{[1
]}

SAITOH, T ^{[1
]}

XIA, Y ^{[1
]}

THAL, LJ ^{[1
]}

KATZMAN, R ^{[1
]}

HILL, LR ^{[1
]}

HANSEN, L ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT NEUROSCI,SAN DIEGO,CA

来源：

NEUROLOGY | 1994年 / 44卷 / 10期

关键词：

D O I：

10.1212/WNL.44.10.1950

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We determined apolipoprotein E (ApoE) genotypes in 122 autopsied demented patients. The frequency of the ApoE epsilon 4 allele was 39.6% in Alzheimer's disease (AD), 29.0% in the Lewy body variant of AD (LBV), and 6.25% in diffuse Lewy body disease. For AD and LBV patients, the epsilon 4 frequency was significantly higher than that reported in nondemented controls (10 to 15%). Therefore, LBV and AD share ApoE epsilon 4 as a genetic risk factor, providing further evidence that these conditions overlap.

引用

页码：1950 / 1951

页数：2

共 10 条

[1] HANSEN L, 1990, NEUROLOGY, V40, P1
[2] HIXSON J, 1991, J LIPID RES, V31, P545
[3] A CLINICOPATHOLOGICAL STUDY OF 100 CASES OF PARKINSONS-DISEASE
HUGHES, AJ
DANIEL, SE
BLANKSON, S
LEES, AJ
[J]. ARCHIVES OF NEUROLOGY, 1993, 50 (02) : 140 - 148
[4] DIAGNOSIS OF ALZHEIMERS-DISEASE
KHACHATURIAN, ZS
[J]. ARCHIVES OF NEUROLOGY, 1985, 42 (11) : 1097 - 1104
[5] THE APOLIPOPROTEIN EPSILON-4 ALLELE IN PARKINSONS-DISEASE WITH AND WITHOUT DEMENTIA
MARDER, K
MAESTRE, G
COTE, L
MEJIA, H
ALFARO, B
HALIM, A
TANG, M
TYCKO, B
MAYEUX, R
[J]. NEUROLOGY, 1994, 44 (07) : 1330 - 1331
[6] APOLIPOPROTEIN-E POLYMORPHISM AND CORONARY-ARTERY DISEASE
MENZEL, HJ
KLADETZKY, RG
ASSMANN, G
[J]. ARTERIOSCLEROSIS, 1983, 3 (04): : 310 - 315
[7] THE NEUROPATHOLOGIC BASIS OF DIFFERENT CLINICAL SUBGROUPS OF PARKINSONS-DISEASE
PAULUS, W
JELLINGER, K
[J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1991, 50 (06) : 743 - 755
[8] ASSOCIATION OF APOLIPOPROTEIN-E ALLELE EPSILON-4 WITH LATE-ONSET FAMILIAL AND SPORADIC ALZHEIMERS-DISEASE
SAUNDERS, AM
STRITTMATTER, WJ
SCHMECHEL, D
GEORGEHYSLOP, PHS
PERICAKVANCE, MA
JOO, SH
ROSI, BL
GUSELLA, JF
CRAPPERMACLACHLAN, DR
ALBERTS, MJ
HULETTE, C
CRAIN, B
GOLDGABER, D
ROSES, AD
[J]. NEUROLOGY, 1993, 43 (08) : 1467 - 1472
[9] APOLIPOPROTEIN-E - HIGH-AVIDITY BINDING TO BETA-AMYLOID AND INCREASED FREQUENCY OF TYPE-4 ALLELE IN LATE-ONSET FAMILIAL ALZHEIMER-DISEASE
STRITTMATTER, WJ
SAUNDERS, AM
SCHMECHEL, D
PERICAKVANCE, M
ENGHILD, J
SALVESEN, GS
ROSES, AD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (05) : 1977 - 1981
[10] APOLIPOPROTEIN-E GENOTYPING BY ONE-STAGE PCR
WENHAM, PR
PRICE, WH
BLUNDELL, G
[J]. LANCET, 1991, 337 (8750) : 1158 - 1159

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