DISCRETE STIMULATORY EFFECTS OF PLATELET-DERIVED GROWTH-FACTOR (PDGF-BB) ON LEYDIG-CELL STEROIDOGENESIS

被引：16

作者：

RISBRIDGER, GP

机构：

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1993年 / 97卷 / 1-2期

关键词：

LEYDIG CELLS; TESTOSTERONE; PLATELET-DERIVED GROWTH FACTOR-BB (PDGF-BB);

D O I：

10.1016/0303-7207(93)90218-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The effect of platelet-derived growth factor-BB on adult rat Leydig cell steroidogenesis has been determined using culture conditions which maintain testosterone production and responsiveness to luteinising hormone for 3 days. A significant stimulation of testosterone levels was observed in acute response to a maximally stimulating dose (8 ng/ml) of rat luteinising hormone on the third day of culture, but was dependent on pre-exposure of the Leydig cells to PDGF-BB for 2 days, whilst maintained in the presence of a minimum dose (0.1 ng/ml) of rat luteinising hormone. These data demonstrate a very discrete action of PDGF-BB on adult rat Leydig cell steroidogenesis in vitro, but whether or not this constitutes a significant paracrine effect in vivo remains to be established.

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页码：125 / 128

页数：4

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