CEPHALOSTATIN CHEMISTRY .5. CHROMIUM[II]-MEDIATED REDUCTIVE CLEAVAGE OF A TERTIARY HALIDE BEARING 3 BETA-ALKOXY GROUPS - SYNTHESIS OF THE NORTH HEXACYCLIC STEROID UNIT OF THE CEPHALOSTATIN FAMILY

被引：15

作者：

KIM, SK ^{[1
]}

SUTTON, SC ^{[1
]}

FUCHS, PL ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT CHEM,W LAFAYETTE,IN 47907

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 14期

关键词：

D O I：

10.1016/0040-4039(95)00307-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Transformation of aldehyde 4 to 17nat, a hexacyclic steroid bearing the requisite functionality and spiroketal stereochemistry of the North portion of the cephalostatin family is described. The key reaction involves CrCl2 mediated reductive cleavage of a tertiary bromide which is beta to three alkoxy groups.

引用

页码：2427 / 2430

页数：4

共 22 条

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