OXYGENATION DURING PERFLUOROCARBON ASSOCIATED GAS-EXCHANGE IN NORMAL AND ABNORMAL LUNGS

被引：10

作者：

HERNAN, LJ ^{[1
]}

FUHRMAN, BP ^{[1
]}

PAPO, MC ^{[1
]}

LEACH, CL ^{[1
]}

THOMPSON, AE ^{[1
]}

NESTI, FD ^{[1
]}

SALMAN, N ^{[1
]}

STEINHORN, DM ^{[1
]}

NOVOTNY, W ^{[1
]}

PACZAN, P ^{[1
]}

BURAK, B ^{[1
]}

RATH, M ^{[1
]}

机构：

[1] CHILDRENS HOSP PITTSBURGH,PITTSBURGH,PA 15213

来源：

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY | 1994年 / 22卷 / 04期

关键词：

D O I：

10.3109/10731199409138840

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Perfluorocarbon-associated gas exchange (PAGE) has been proposed for the treatment of lung diseases characterized by high alveolar surface tension. Perflubron (perfluorooctyl bromide, LiquiVent(tm), Alliance Pharmaceutical Corp.) is a high purity medical grade perfluorocarbon suitable for PAGE. We studied PAGE using perflubron in normal piglets and in animal models of pulmonary disease (meconium aspiration syndrome, oleic acid infusion and gastric acid aspiration as models of ARDS, and neonatal respiratory distress syndrome). All animals were studied under anesthesia. PAGE was instituted by intratracheal instillation of a volume of perflubron (generally 30 ml/kg) that approximates a normal functional residual capacity of the lung. Arterial blood gases were measured at 15 minute intervals. FiO(2) during PAGE was 1.0. In normal piglets, PaO2 fell from 543 torr (during conventional gas breathing) to 363 torr (during PAGE). However, in models of lung disease, PAGE significantly enhanced PaO2.

引用

页码：1377 / 1380

页数：4