HUMAN ALPHA-B-CRYSTALLIN (CRYA2) GENE MAPPED TO CHROMOSOME 11Q12-Q23

被引：23

作者：

BRAKENHOFF, RH

VANKESSEL, AHMG

OLDENBURG, M

WIJNEN, JT

BLOEMENDAL, H

KHAN, PM

SCHOENMAKERS, JGG

机构：

[1] CATHOLIC UNIV NIJMEGEN,DEPT MOLEC BIOL & CELL BIOL,6525 ED NIJMEGEN,NETHERLANDS

[2] CATHOLIC UNIV NIJMEGEN,DEPT HUMAN GENET,6500 HB NIJMEGEN,NETHERLANDS

[3] CATHOLIC UNIV NIJMEGEN,DEPT BIOCHEM,6500 HB NIJMEGEN,NETHERLANDS

[4] LEIDEN STATE UNIV,SYLVIUS LAB,INST HUMAN GENET,2312 AV LEIDEN,NETHERLANDS

来源：

HUMAN GENETICS | 1990年 / 85卷 / 02期

关键词：

D O I：

10.1007/BF00193203

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The αB-crystallin gene (CRYA2) encodes the abundant lens protein αB-crystallin. A panel of human/ rodent hybrid cell lines, derived from five different parental combinations, was characterized with respect to human chromosomal content and the presence of well-established human chromosome-specific markers. This panel was screened for the presence of CRYA2, using the third exon of the hamster αB-crystallin gene as a probe. The patterns of segregation of CRYA2 with individual human chromosomes show the highest degree of concordance between CRYA2 and chromosome 11. Using cell hybrids containing translocated and/or partially deleted human chromosomes, the CRYA2 gene was localized to 11q12-11q23. © 1990 Springer-Verlag.

引用

页码：237 / 240

页数：4

共 17 条

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