OPIATE-RECEPTORS IN SUBSTANTIA NIGRA - ROLE IN THE REGULATION OF STRIATAL TYROSINE-HYDROXYLASE ACTIVITY

被引：21

作者：

GALE, K ^{[1
]}

MORONI, F ^{[1
]}

KUMAKURA, K ^{[1
]}

GUIDOTTI, A ^{[1
]}

机构：

[1] ST ELIZABETHS HOSP,NIMH,PRECLIN PHARMACOL LAB,WASHINGTON,DC 20032

来源：

NEUROPHARMACOLOGY | 1979年 / 18卷 / 04期

关键词：

D O I：

10.1016/0028-3908(79)90153-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Morphine injected into the substantia nigra (SN) of rats failed to change DA metabolism in striatum but blocked the haloperidol induced activation of striatal tyrosine hydroxylase (TH). This blockade was mediated by stimulation of opiate receptors in SN because it was antagonized by naltrexone. The binding of 3H-enkephalinamide to opiate receptors in SN was not altered after lesion of the nigrostriatal DA pathways with 6-hydroxydopamine but was decreased (approximately 70%) after brain hemitransection. These results suggest that intranigral morphine prevents the haloperidol induced activation of striatal TH by modulating the release of endogenous transmitters or modulators on DA neurons. © 1979.

引用

页码：427 / 430

页数：4

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