EFFECT OF CYCLOSPORINE-A AND OLIGOMYCIN ON NONSPECIFIC PERMEABILITY OF THE INNER MITOCHONDRIAL-MEMBRANE

被引：26

作者：

NOVGORODOV, SA ^{[1
]}

GUDZ, TI ^{[1
]}

KUSHNAREVA, YE ^{[1
]}

ZOROV, DB ^{[1
]}

KUDRJASHOV, YB ^{[1
]}

机构：

[1] MV LOMONOSOV STATE UNIV,FAC BIOL,DEPT BIOPHYS,MOSCOW 11989,USSR

来源：

FEBS LETTERS | 1990年 / 270卷 / 1-2期

关键词：

Cyclosporine A; Mitochondria; Non-specific permeability;

D O I：

10.1016/0014-5793(90)81245-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of oligomycin and cyclosporine A on the induction of non-specific permeability of the inner mitochondrial membrane by Ca2+ was under study. Both oligomycin and cyclosporine A were able to prevent the activation of non-specific permeability, but cyclosporine A was the only agent which could restore initial permeability of the inner mitochondrial membrane. The effect of cyclosporine A was shown not to be mediated through redistribution of Ca2+ between different mitochondrial subpopulations. © 1990.

引用

页码：108 / 110

页数：3

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