SULFONYLUREAS ACTIVATE GLUCOSE-TRANSPORT AND PROTEIN-KINASE-C IN RAT ADIPOCYTES

被引：29

作者：

FARESE, RV

ISHIZUKA, T

STANDAERT, ML

COOPER, DR

机构：

[1] VET ADM MED CTR, TAMPA, FL USA

[2] UNIV S FLORIDA, COLL MED, DEPT INTERNAL MED, TAMPA, FL 33612 USA

[3] UNIV S FLORIDA, COLL MED, DEPT BIOCHEM, TAMPA, FL 33612 USA

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1991年 / 40卷 / 02期

关键词：

D O I：

10.1016/0026-0495(91)90174-U

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glyburide and tolbutamide, at concentrations of 20 to 40 μmol/L and 1 to 2 mmol/L, respectively, stimulated glucose transport in rat adipocytes. Concomitantly, protein kinase C was activated, as evidenced by translocation of immunoreactive enzyme from cytosol to membranes. Glucose transport effects of the sulfonylureas were blocked by three inhibitors of protein kinase C (H-7, staurosporine, and sangivamycin), and by phorbol ester-induced down-regulation of protein kinase C. These findings suggest that sulfonylureas may stimulate glucose transport in rat adipocytes through activation of protein kinase C. © 1991.

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页码：196 / 200

页数：5

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