HIV REPLICATION AND PERSISTENCE IN HUMAN GASTROINTESTINAL CELLS CULTURED INVITRO

被引：20

作者：

MOYER, MP

GENDELMAN, HE

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DEPT MICROBIOL,CTR HUMAN CELL BIOTECHNOL,SAN ANTONIO,TX 78284

[2] UNIFORMED SERV UNIV HLTH SCI,HENRY M JACKSON FDN,BETHESDA,MD 20814

[3] WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,HIV IMMUNOPATHOGENESIS PROGRAM,WASHINGTON,DC 20307

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 1991年 / 49卷 / 05期

关键词：

ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS); VIRUS PERSISTENCE; VIRUS LATENCY; CELL CULTURE MODELS; KAPOSIS SARCOMA;

D O I：

10.1002/jlb.49.5.499

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epithelial and submucosal mesenchymal (SM) cells from normal human small intestine and colon could be directly infected by several strains of the human immunodeficiency virus (HIV). Macrophage-derived virus strains were more potent than the HTLVIIIB prototype strain. Persistent release of virus over several months implies that the human gastrointestinal tract may serve as a site for primary infection and as a reservoir for the virus. Furthermore, HIV infection of SM cells may be an in vitro model of Kaposi's sarcoma.

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页码：499 / 504

页数：6

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