THYROID-HORMONE RESISTANCE SYNDROMES

被引：26

作者：

USALA, SJ ^{[1
]}

WEINTRAUB, BD ^{[1
]}

机构：

[1] NIH,MOLEC CELLULAR & NUTR ENDOCRINOL BRANCH,BETHESDA,MD 20892

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1991年 / 2卷 / 04期

关键词：

D O I：

10.1016/1043-2760(91)90004-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The gene for generalized thyroid hormone resistance has been mapped to the c-erbA-beta thyroid hormone receptor on chromosome 3 in multiple kindreds. Different mutations have been identified in the triiodothyronine (T3)-binding domain of c-erbA-beta and result in variable changes in T3-binding affinity. The variant phenotypes of thyroid hormone resistance are likely due to different mutations in the c-erbA-beta receptor.

引用

页码：140 / 144

页数：5

共 26 条

[1] A CDNA PROBE (PHEA12) FROM THE HC-(ERBA) GENE ON CHROMOSOME-3 DETECTS A HIGH-FREQUENCY RFLP [J].

BALE, AE ;

USALA, S ;

WEINBERGER, C ;

WEINTRAUB, BD ;

MCBRIDE, OW .

NUCLEIC ACIDS RESEARCH, 1988, 16 (15) :7756-7756

[2]

BURNSIDE J, 1990, J BIOL CHEM, V265, P2500

[3]

FEIN HG, 1989, 64TH P M AM THYR ASS

[4] A DOMAIN CONTAINING LEUCINE-ZIPPER-LIKE MOTIFS MEDIATE NOVEL INVIVO INTERACTIONS BETWEEN THE THYROID-HORMONE AND RETINOIC ACID RECEPTORS [J].

FORMAN, BM ;

YANG, CR ;

AU, M ;

CASANOVA, J ;

GHYSDAEL, J ;

SAMUELS, HH .

MOLECULAR ENDOCRINOLOGY, 1989, 3 (10) :1610-1626

[5] THYROTROPIN-INDUCED HYPERTHYROIDISM CAUSED BY SELECTIVE PITUITARY RESISTANCE TO THYROID-HORMONE - NEW SYNDROME OF INAPPROPRIATE SECRETION OF TSH [J].

GERSHENGORN, MC ;

WEINTRAUB, BD .

JOURNAL OF CLINICAL INVESTIGATION, 1975, 56 (03) :633-642

[6]

GLASS CK, 1989, CELL, V59, P677

[7] FUNCTIONAL INACTIVATION OF GENES BY DOMINANT NEGATIVE MUTATIONS [J].

HERSKOWITZ, I .

NATURE, 1987, 329 (6136) :219-222

[8] PARTIAL PERIPHERAL RESISTANCE TO THYROID-HORMONE [J].

KAPLAN, MM ;

SWARTZ, SL ;

LARSEN, PR .

AMERICAN JOURNAL OF MEDICINE, 1981, 70 (05) :1115-1121

[9] FAMILIAL GENERALIZED RESISTANCE TO THYROID-HORMONES - REPORT OF 3 KINDREDS AND CORRELATION OF PATTERNS OF AFFECTED TISSUES WITH THE BINDING OF [I-125] TRIIODOTHYRONINE TO FIBROBLAST NUCLEI [J].

MAGNER, JA ;

PETRICK, P ;

MENEZESFERREIRA, MM ;

STELLING, M ;

WEINTRAUB, BD .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 1986, 9 (06) :459-470

[10] IDENTIFICATION OF NUCLEAR FACTORS THAT ENHANCE BINDING OF THE THYROID-HORMONE RECEPTOR TO A THYROID-HORMONE RESPONSE ELEMENT [J].

MURRAY, MB ;

TOWLE, HC .

MOLECULAR ENDOCRINOLOGY, 1989, 3 (09) :1434-1442

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