STRUCTURE AND FUNCTION OF TELOMERES

被引：3164

作者：

BLACKBURN, EH ^{[1
]}

机构：

[1] DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

来源：

NATURE | 1991年 / 350卷 / 6319期

关键词：

D O I：

10.1038/350569a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The DNA of telomeres - the terminal DNA-protein complexes of chromosomes - differs notably from other DNA sequences in both structure and function. Recent work has highlighted its remarkable mode of synthesis by the ribonucleoprotein reverse transcriptase, telomerase 1-4, as well as its ability to form unusual structures in vitro. Moreover, telomere synthesis by telomerase has been shown to be essential for telomere maintenance and long-term viability.

引用

页码：569 / 573

页数：5

共 72 条

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