COLOCALIZATION OF LYMPHOCYTES BEARING GAMMA-DELTA-T-CELL RECEPTOR AND HEAT-SHOCK PROTEIN HSP65+ OLIGODENDROCYTES IN MULTIPLE-SCLEROSIS

被引:260
作者
SELMAJ, K
BROSNAN, CF
RAINE, CS
机构
[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT NEUROSCI, BRONX, NY 10461 USA
[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED, ROSE F KENNEDY CTR RES MENTAL RETARDAT & HUMAN DEV, BRONX, NY 10461 USA
关键词
D O I
10.1073/pnas.88.15.6452
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The presence of T lymphocytes bearing the gamma-delta-T-cell receptor (TCR-gamma-delta) has been studied immunocytochemically in central nervous system (CNS) tissue from 13 patients with multiple sclerosis (MS), 4 with inflammatory non-MS CNS disorders, 6 with other neurological diseases, and 3 with nonneurologic conditions. Twenty-eight of 43 MS lesions contained TCR-gamma-delta-cells and these were most frequently found in chronically demyelinated areas, in contrast to the previously studied CD4+, CD8+ (TCR-alpha-beta) population, which predominated in more active lesions. Some TCR-gamma-delta-lymphocytes had an unusual morphology with long dendritic processes, which were sometimes interconnected forming a network. Because it is generally believed that TCR-gamma-delta-lymphocytes function in a cytotoxic fashion in association with heat shock proteins (hsp), we examined the colocalization of TCR-gamma-delta-cells with 65- and 70-kDa hsp (hsp65 and hsp70) in MS lesions. Hsp65 was expressed on immature oligodendrocytes at the margins of chronic lesions containing TCR-gamma-delta-lymphocytes. The coexpression of these molecules might imply functional relationships perhaps of significance to the chronicity of the MS disease process and the failure of CNS remyelination.
引用
收藏
页码:6452 / 6456
页数:5
相关论文
共 47 条
  • [1] FUNCTIONAL GAMMA-CHAIN ASSOCIATED T-CELL RECEPTORS ON CEREBROSPINAL-FLUID DERIVED NATURAL-KILLER LIKE T-CELL CLONES
    ANG, SL
    SEIDMAN, JG
    PETERMAN, GM
    DUBY, AD
    BENJAMIN, D
    LEE, SJ
    HAFLER, DA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 165 (05) : 1453 - 1458
  • [2] INCREASED NUMBERS OF LYMPHOCYTE-T WITH GAMMA-DELTA-POSITIVE ANTIGEN RECEPTORS IN A SUBGROUP OF INDIVIDUALS WITH PULMONARY SARCOIDOSIS
    BALBI, B
    MOLLER, DR
    KIRBY, M
    HOLROYD, KJ
    CRYSTAL, RG
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (05) : 1353 - 1361
  • [3] IMMUNOCHEMICAL PROOF THAT A NOVEL REARRANGING GENE ENCODES THE T-CELL RECEPTOR-DELTA SUBUNIT
    BAND, H
    HOCHSTENBACH, F
    MCLEAN, J
    HATA, S
    KRANGEL, MS
    BRENNER, MB
    [J]. SCIENCE, 1987, 238 (4827) : 682 - 684
  • [4] REGULATION OF TRANSCRIPTION OF THE HUMAN T-CELL ANTIGEN RECEPTOR DELTA CHAIN GENE - A T-LINEAGE SPECIFIC ENHANCER ELEMENT IS LOCATED IN THE J-DELTA-3-C-DELTA INTRON
    BORIES, JC
    LOISEAU, P
    DAURIOL, L
    GONTIER, C
    BENSUSSAN, A
    DEGOS, L
    SIGAUX, F
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (01) : 75 - 83
  • [5] BORN W, 1990, IMMUNOL TODAY, V11, P40
  • [6] A T-CELL RECEPTOR GAMMA-CD3 COMPLEX FOUND ON CLONED FUNCTIONAL LYMPHOCYTES
    BORST, J
    VANDEGRIEND, RJ
    VANOOSTVEEN, JW
    ANG, SL
    MELIEF, CJ
    SEIDMAN, JG
    BOLHUIS, RLH
    [J]. NATURE, 1987, 325 (6106) : 683 - 688
  • [7] 2 SUBSETS OF HUMAN LYMPHOCYTES-T EXPRESSING GAMMA-ANTIGEN DELTA-ANTIGEN RECEPTOR ARE IDENTIFIABLE BY MONOCLONAL-ANTIBODIES DIRECTED TO 2 DISTINCT MOLECULAR-FORMS OF THE RECEPTOR
    BOTTINO, C
    TAMBUSSI, G
    FERRINI, S
    CICCONE, E
    VARESE, P
    MINGARI, MC
    MORETTA, L
    MORETTA, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (02) : 491 - 505
  • [8] BRENNER MB, 1987, J IMMUNOL, V138, P1502
  • [9] 2 FORMS OF THE T-CELL RECEPTOR GAMMA-PROTEIN FOUND ON PERIPHERAL-BLOOD CYTOTOXIC T-LYMPHOCYTES
    BRENNER, MB
    MCLEAN, J
    SCHEFT, H
    RIBERDY, J
    ANG, SL
    SEIDMAN, JG
    DEVLIN, P
    KRANGEL, MS
    [J]. NATURE, 1987, 325 (6106) : 689 - 694
  • [10] MOLECULAR ANALYSIS OF HUMAN GAMMA-DELTA+ CLONES FROM THYMUS AND PERIPHERAL-BLOOD
    CASORATI, G
    DELIBERO, G
    LANZAVECCHIA, A
    MIGONE, N
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (05) : 1521 - 1535