STUDIES ON THE METABOLISM OF THE ANTIOXIDANT ETHOXYQUIN, 6-ETHOXY-2,2,4-TRIMETHYL-1,2-DIHYDROQUINOLINE IN THE RAT

被引：26

作者：

SKAARE, JU ^{[1
]}

SOLHEIM, E ^{[1
]}

机构：

[1] UNIV BERGEN,HAUKELAND HOSP,SCH MED,DEPT PHARMACOL,N-5016 BERGEN,NORWAY

来源：

XENOBIOTICA | 1979年 / 9卷 / 11期

关键词：

D O I：

10.3109/00498257909042332

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The metabolism of ethoxyquin (6-ethoxy-2,2,4-trimethyl-1, 2-dihydroquinoline) in rat has been investigated. Urinary metabolites were identified by combined g.l.c.-mass spectrometry. 2. The major metabolic reaction was de-ethylation which gave rise to 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline and an oxidation product, 2,2,4-trimethyl-6-quinolone. Other reactions were hydroxylation to four different hydroxylated metabolites and one dihydroxylated metabolite. A total of 95% of the dose (100mg/kg) was accounted for. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：649 / 657

页数：9

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