MICROBIAL TRANSFORMATION OF DITERPENES - HYDROXYLATION OF SCLAREOL, MANOOL AND DERIVATIVES BY MUCOR-PLUMBEUS

被引：64

作者：

ARANDA, G

ELKORTBI, MS

LALLEMAND, JY

NEUMAN, A

HAMMOUMI, A

FACON, I

AZERAD, R

机构：

[1] UFR BIOMED,CHIM BIOORGAN STRUCT LAB,F-93012 BOBIGNY,FRANCE

[2] UNIV PARIS 05,CHIM & BIOCHIM PHARMACOL & TOXICOL LAB,CNRS,URA 400,F-75270 PARIS 06,FRANCE

来源：

TETRAHEDRON | 1991年 / 47卷 / 39期

关键词：

MUCOR-PLUMBEUS; MICROBIOLOGICAL TRANSFORMATION; DITERPENES; SCLAREOL AND MANOOL DERIVATIVES; STRUCTURAL DETERMINATION;

D O I：

10.1016/S0040-4020(01)96175-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Microbial transformation of several labd-14-ene derivatives has been carried out with a Mucor plumbeus strain. Sclareol (1) (labd-14-en-8-alpha,13-beta-diol) affords quantitatively a mixture of triols from which the labd-14-en-3-beta,8-alpha,13-beta-triol (2) is obtained in high yield. Incubation of other labdane derivatives, including manool (6) [labd-8(17),14-dien-13-beta-ol], the corresponding 7-alpha-hydroxy derivative (10), manoyl oxide (14) or sclareolide (15) with the same microorganism results in a mixture of various new hydroxylated and keto- derivatives.

引用

页码：8339 / 8350

页数：12

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