CYTOCHROME-B OF PROTOZOAN MITOCHONDRIA - RELATIONSHIPS BETWEEN FUNCTION AND STRUCTURE

被引：13

作者：

GHELLI, A

CRIMI, M

ORSINI, S

GRADONI, L

ZANNOTTI, M

LENAZ, G

ESPOSTI, MD

机构：

[1] UNIV BOLOGNA,DEPT BIOL,BOT SECT,VIA IRNERIO 42,I-40126 BOLOGNA,ITALY

[2] UNIV BOLOGNA,IST ISTOL,FAC MED & CHIRURG,I-40126 BOLOGNA,ITALY

[3] IST SUPER SANITA,DEPT PARASITOL,I-00161 ROME,ITALY

[4] UNIV BOLOGNA,DIPARTIMENTO BIOCHIM,I-40126 BOLOGNA,ITALY

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1992年 / 103卷 / 02期

关键词：

D O I：

10.1016/0305-0491(92)90300-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The sensitivity of ubiquinol: cytochrome c reductase to its most powerful inhibitors has been characterized in mitochondria from three ciliate and two trypanosome protozoans and compared with that in mitochondria of animals and plants. 2. Mitochondria of ciliates, particularly those of Tetrahymena pyriformis, are resistant to antimycin. 3. Mitochondria of trypanosomes are quite resistant to stigmatellin, as they exhibit a 40-fold higher titer than that in ciliate or animals mitochondria. 4. Both ciliates and trypanosomes are highly resistant to myxothiazol. 5. Correlations have been drawn between the natural resistance of the protozoan mitochondria to antimycin, stigmatellin and myxothiazol and peculiar features in the structure of their apocytochrome b, on the basis of an accurate alignment of the sequences of this protein.

引用

页码：329 / 338

页数：10

共 61 条

[1] SEQUENCE IDENTIFICATION OF CYTOCHROME-B IN PLASMODIUM-GALLINACEUM [J].