INSULIN-LIKE GROWTH FACTOR-II STIMULATES GLUCOSE-TRANSPORT IN HUMAN SKELETAL-MUSCLE

被引：24

作者：

ZIERATH, JR ^{[1
]}

BANG, P ^{[1
]}

GALUSKA, D ^{[1
]}

HALL, K ^{[1
]}

WALLBERGHENRIKSSON, H ^{[1
]}

机构：

[1] KAROLINSKA HOSP,KAROLINSKA INST,DEPT ENDOCRINOL,S-10401 STOCKHOLM 60,SWEDEN

来源：

FEBS LETTERS | 1992年 / 307卷 / 03期

关键词：

3-O-METHYLGLUCOSE TRANSPORT; INSULIN-LIKE GROWTH FACTOR-II; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-1; INSULIN;

D O I：

10.1016/0014-5793(92)80717-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effect of insulin-like growth factor II (IGF-II)and insulin-like growth factor binding protein-1 (IGFBP-1)on 3-O-methylglucose transport in incubated human skeletal muscle strips. Increasing physiological concentrations of IGF-II stimulated glucose transport in a dose-dependent manner. Glucose transport was maximally stimulated in the presence of 100 ng/ml (13.4 nM) of IGF-II, which corresponded to the effect obtained by 100-mu-U/ml (0.6 nM) of insulin. Exposure of muscle strips to IGFBP-1 (500 ng/ml) inhibited the maximal effect of IGF-II on glucose transport by 40%. Thus, it is conceivable that IGF-II and IGFBP-1 are physiological regulators of the glucose transport process in human skeletal muscle.

引用

页码：379 / 382

页数：4

共 30 条

[1] DECREASED INSULIN-STIMULATED 3-0-METHYLGLUCOSE TRANSPORT IN INVITRO INCUBATED MUSCLE STRIPS FROM TYPE-II DIABETIC SUBJECTS [J].

ANDREASSON, K ;

GALUSKA, D ;

THORNE, A ;

SONNENFELD, T ;

WALLBERGHENRIKSSON, H .

ACTA PHYSIOLOGICA SCANDINAVICA, 1991, 142 (02) :255-260

[2] EXERCISE-INDUCED CHANGES IN INSULIN-LIKE GROWTH-FACTORS AND THEIR LOW-MOLECULAR-WEIGHT BINDING-PROTEIN IN HEALTHY-SUBJECTS AND PATIENTS WITH GROWTH-HORMONE DEFICIENCY [J].

BANG, P ;

BRANDT, J ;

DEGERBLAD, M ;

ENBERG, G ;

KAIJSER, L ;

THOREN, M ;

HALL, K .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1990, 20 (03) :285-292

[3] COMPARISON OF ACID ETHANOL EXTRACTION AND ACID GEL-FILTRATION PRIOR TO IGF-I AND IGF-II RADIOIMMUNOASSAYS - IMPROVEMENT OF DETERMINATIONS IN ACID ETHANOL EXTRACTS BY THE USE OF TRUNCATED IGF-I AS RADIOLIGAND [J].

BANG, P ;

ERIKSSON, U ;

SARA, V ;

WIVALL, IL ;

HALL, K .

ACTA ENDOCRINOLOGICA, 1991, 124 (06) :620-629

[4] INSULIN DIFFERENTIALLY ALTERS TRANSCAPILLARY MOVEMENT OF INTRAVASCULAR IGFBP-1, IGFBP-2 AND ENDOTHELIAL-CELL IGF-BINDING PROTEINS IN THE RAT-HEART [J].

BAR, RS ;

BOES, M ;

CLEMMONS, DR ;

BUSBY, WH ;

SANDRA, A ;

DAKE, BL ;

BOOTH, BA .

ENDOCRINOLOGY, 1990, 127 (01) :497-499

[5] INSULIN-LIKE GROWTH FACTOR-I (IGF-I)-BINDING PROTEIN COMPLEX IS A BETTER MITOGEN THAN FREE IGF-I [J].

BLUM, WF ;

JENNE, EW ;

REPPIN, F ;

KIETZMANN, K ;

RANKE, MB ;

BIERICH, JR .

ENDOCRINOLOGY, 1989, 125 (02) :766-772

[6] INSULIN REGULATES THE 35-KDA IGF BINDING-PROTEIN IN PATIENTS WITH DIABETES-MELLITUS [J].

BRISMAR, K ;

GUTNIAK, M ;

POVOA, G ;

WERNER, S ;

HALL, K .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 1988, 11 (08) :599-602

[7] SERUM HALF-LIFE AND BIOLOGICAL-ACTIVITY OF MUTANTS OF HUMAN INSULIN-LIKE GROWTH FACTOR-I WHICH DO NOT BIND TO SERUM BINDING-PROTEINS [J].

CASCIERI, MA ;

SAPERSTEIN, R ;

HAYES, NS ;

GREEN, BG ;

CHICCHI, GG ;

APPLEBAUM, J ;

BAYNE, ML .

ENDOCRINOLOGY, 1988, 123 (01) :373-381

[8] ALTERATIONS IN THE SYNTHESIS OF A FIBROBLAST SURFACE ASSOCIATED 35-K PROTEIN MODULATES THE BINDING OF SOMATOMEDIN-C INSULIN-LIKE GROWTH FACTOR-I [J].

CLEMMONS, DR ;

HAN, VKM ;

ELGIN, RG ;

DERCOLE, AJ .

MOLECULAR ENDOCRINOLOGY, 1987, 1 (05) :339-347

[9] IGF-I STIMULATED GLUCOSE-TRANSPORT IN HUMAN SKELETAL-MUSCLE AND IGF-I RESISTANCE IN OBESITY AND NIDDM [J].

DOHM, GL ;

ELTON, CW ;

RAJU, MS ;

MOONEY, ND ;

DIMARCHI, R ;

PORIES, WJ ;

FLICKINGER, EG ;

ATKINSON, SM ;

CARO, JF .

DIABETES, 1990, 39 (09) :1028-1032

[10] AN INVITRO HUMAN MUSCLE PREPARATION SUITABLE FOR METABOLIC STUDIES - DECREASED INSULIN STIMULATION OF GLUCOSE-TRANSPORT IN MUSCLE FROM MORBIDLY OBESE AND DIABETIC SUBJECTS [J].

DOHM, GL ;

TAPSCOTT, EB ;

PORIES, WJ ;

DABBS, DJ ;

FLICKINGER, EG ;

MEELHEIM, D ;

FUSHIKI, T ;

ATKINSON, SM ;

ELTON, CW ;

CARO, JF .

JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (02) :486-494

← 1 2 3 →