Adrenergic Bloc ade of Hypocapnic Cerebral Arterial Constriction

被引：5

作者：

Fraser, Richard A. R. ^{[1
]}

Stein, Bennett M. ^{[1
]}

Pool, J. Lawrence ^{[1
]}

机构：

[1] Columbia Univ, Dept Neurol Surg, Neurol Inst New York, 710 West 168th St, New York, NY 10032 USA

来源：

STROKE | 1971年 / 2卷 / 03期

关键词：

cerebral blood flow; phenoxybenzamine; alpha receptor; catecholamine fluorescence; autoregulation;

D O I：

10.1161/01.STR.2.3.219

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Hypocapnic constriction of the basilar and vertebral arteries was produced and pharmacologically modified (by intrathecal administration) in nine Rhesus monkeys. The arteries were then removed and studied with a catecholamine fluorescent technique, Alterations in P-C02 were associated with significant changes in the caliber of large arteries. Mere depletion of the periarterial norepinephrine stores did not prevent hypocapnic vasoconstriction. The latter was reversed, however, by alpha adrenergic blockade (phenoxybenz,arnine). The alpha adrenergic receptor appears to he a mediating site for hypocapnic constriction of the intracranial vessels. We have proposed that the alpha receptor may be H+ sensitive so that changes in pH alter the responsiveness of the adrenergic receptor to transmitter substances.y

引用

页码：219 / 231

页数：13

共 58 条

[1]

Bayliss WM, 1902, J PHYSIOL-LONDON, V28, P220

[2] CEREBRAL CORTICAL BLOOD FLOW DURING CHANGES OF ACID-BASE EQUILIBRIUM OF BRAIN [J].