SYNTHESIS AND DNA-CLEAVING PROPERTIES OF HYBRID MOLECULES CONTAINING PROPARGYLIC SULFONES AND MINOR-GROOVE BINDING LEXITROPSINS

被引：24

作者：

XIE, GJ

MORGAN, AR

LOWN, JW

机构：

[1] UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2G2,ALBERTA,CANADA

[2] UNIV ALBERTA,DEPT BIOCHEM,EDMONTON T6G 2H7,ALBERTA,CANADA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80019-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of hybrids incorporating propargylic sulfones and minor groove binding oligopeptide carriers 2-11 were synthesized and their abilities to cleave DNA have been demonstrated.

引用

页码：1565 / 1570

页数：6

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