CLINICOPATHOLOGICAL CORRELATION OF AN EPIRETINAL MEMBRANE-ASSOCIATED WITH A RECURRENT MACULAR HOLE

被引：56

作者：

FEKRAT, S ^{[1
]}

WENDEL, RT ^{[1
]}

DELACRUZ, Z ^{[1
]}

GREEN, WR ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV HOSP,EYE PATHOL LAB,BALTIMORE,MD 21287

来源：

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 1995年 / 15卷 / 01期

关键词：

EPIRETINAL MEMBRANE; FIBROUS ASTROCYTES; MACULAR HOLE; MULLER CELLS; PATHOGENESIS; RECURRENT; TANGENTIAL TRACTION; VITRECTOMY;

D O I：

10.1097/00006982-199515010-00010

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To describe the clinicopathologic features of an epiretinal membrane associated with a recurrent, full-thickness idiopathic macular hole and speculate on the mechanism(s) contributing to its recurrence 1 year after initially successful closure of pars plana vitrectomy and gas tamponade (SF6). Methods: After fixation of the 2 X 1 mm specimen in a mixture of 1% glutaraldehyde and 4% formaldehyde followed by 2.5% glutaraldehyde, postfixation with osmium tetroxide, and standard dehydration, the specimen was embedded in epoxy resin. Ultrathin sections were stained with uranyl acetate and lead citrate for transmission electron microscopy. Results: Ultrastructural examination disclosed a fibrocellular membrane composed of Muller cells and fibrous astrocytes. Native collagen was entrapped in the matrix in some areas, Conclusion: Those cells that may lead to the closure of an idiopathic macular hole may also contribute to its recurrence if the reparative process goes awry.

引用

页码：53 / 57

页数：5

共 12 条

[1] Gass J.D.M., Idiopathic senile macular hole: Its early stages and pathogenesis, Arch Ophthalmol, 106, pp. 629-639, (1988)
[2] Johnson R.N., Gass J.D.M., Idiopathic macular holes: Observations, stages of formation, and implications for surgical intervention, Ophthalmology, 95, pp. 917-924, (1988)
[3] Guyer D.R., Green W.R., Idiopathic macular holes and precursor lesions, Franklin RM, pp. 135-162, (1993)
[4] Funata M., Wendel R.T., Cruz D.L.Z., Green W.R., Clinicopathologic study of bilateral macular holes treated with pars plana vitrectomy and gas tamponade, Retina, 12, pp. 289-298, (1992)
[5] Madreperla S.A., Geiger G.L., Funata M., Cruz D.L.Z., Green W.R., Clinicopathologic correlation of a macular hole treated by a cortical vitreous peeling and gas tamponade, Ophthalmology, 101, pp. 682-686, (1994)
[6] Kuhnt H., Ueber eine eigenthomliche veranderung der netz- haut ad maculam, Z Augenheilk, 3, (1900)
[7] Smiddy W.E., Michels R.G., De Bustros S., Cruz D.L.Z., Green W.R., Histopathology of tissue removed during vitrectomy for impending idiopathic macular holes, Am J Ophthalmol, 108, pp. 360-364, (1989)
[8] Smiddy W.E., Michels R.G., Glaser B.M., De Bustros S., Vitrectomy for impending macular holes, Am J Ophthalmol, 105, pp. 371-376, (1988)
[9] Guyer D.R., Green W.R., De Bustros S., Fine S.L., Histopathologic features of idiopathic macular holes and cysts, Ophthalmology, 97, pp. 1045-1051, (1990)
[10] Foos R.Y., Gloor B.P., Vitreoretinal junction: Healing of experimental wounds, Graefes Arch Clin Exp Ophthalmol, 196, pp. 213-230, (1975)

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