TEMPORAL PATTERN OF INTERNUCLEOSOMAL DNA FRAGMENTATION IN THE STRIATUM AND HIPPOCAMPUS AFTER TRANSIENT FOREBRAIN ISCHEMIA

被引：31

作者：

VOLPE, BT

WESSEL, TC

MUKHERJEE, B

FEDEROFF, HJ

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10461 USA

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT NEUROSCI, BRONX, NY 10461 USA

[3] CORNELL UNIV, SCH MED, BURKE MED RES INST, DEPT NEUROL & NEUROSCI, WHITE PLAINS, NY 10605 USA

来源：

NEUROSCIENCE LETTERS | 1995年 / 186卷 / 2-3期

关键词：

APOPTOSIS; PROGRAM CELL DEATH; ISCHEMIA; HIPPOCAMPUS; STRIATUM;

D O I：

10.1016/0304-3940(95)11310-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transient forebrain ischemia in rodents caused internucleosomal DNA fragmentation that appeared in the striatum 24 h after reperfusion, and in the hippocampus 72 h after reperfusion. Gel electrophoresis and an in situ technique to label 3' termini of endonuclease generated DNA fragments demonstrated similar temporal patterns. These data show that endonuclease activation accompanies the demise of selectively vulnerable neurons following transient forebrain ischemia.

引用

页码：157 / 160

页数：4

共 23 条

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