NEAR-VISIBLE-UV RADIATION DELAYS UVB TUMORIGENESIS

The effect of UVA radiation (321-400 nm) on UVB photocarcinogenesis was examined in lightly pigmented hairless hr/hr C3H/Tif mice. Five groups of 22 mice were exposed to UVB radiation (281-320 nm) from one Philips 12 tube for 10 min per day and 4 days per week. Four of the groups were simultaneously exposed to UVA from two to six filtered Philips 09 tubes. The daily dose of UVB was 2.0 kJ m(-2) in all five groups; the UVA2 (321-340 nm) dose varied from 0.7 to 4.5 kJ m(-2) and the UVA1 (341-400 nm) dose from 0.3 to 45.6 kJ m(-2). A sixth group was exclusively irradiated with the filtered UVA tubes and served as a control. Skin tumor development was not significantly different for the groups exposed to the UVB source alone or the UVB source in combination with the largest daily UVA dose (0.2>p>O.1). Skin tumor development was significantly delayed in the other groups irradiated with the UVB source and the lower doses of UVA (p<0.001). No tumors were observed in the control group. This study suggests that UVA1. radiation delays UVB-induced skin tumor development. However, the delay cannot be expected to persist when UVA is administered in higher daily doses.