INCREASE IN NEURONAL JUN IMMUNOREACTIVITY AND EPIDERMAL NGF LEVELS FOLLOWING UV EXPOSURE OF RAT SKIN

被引：22

作者：

GILLARDON, F ^{[1
]}

ESCHENFELDER, C ^{[1
]}

RUSH, RA ^{[1
]}

ZIMMERMAN, M ^{[1
]}

机构：

[1] FLINDERS UNIV S AUSTRALIA,DEPT HUMAN PHYSIOL,ADELAIDE,SA 5001,AUSTRALIA

来源：

NEUROREPORT | 1995年 / 6卷 / 09期

关键词：

ULTRAVIOLET RADIATION; EPIDERMIS; NERVE GROWTH FACTOR; NEURON DAMAGE; ELECTRON MICROSCOPY; DORSAL ROOT GANGLIA; JUN; IMMUNOHISTOCHEMISTRY;

D O I：

10.1097/00001756-199506090-00023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

EFFECTS of cutaneous ultraviolet (UV) irradiation on superficial nerve fibres are controversial. In the present study we demonstrate by electron microscopy that single high-dose UV exposure of rat skin results in membrane damage in peripheral nerves. Furthermore, a UV-induced accumulation of nerve growth factor (NGF) within the irradiated epidermis and a delayed increase in nuclear Jun immunoreactivity in dorsal root ganglion neurones were detected by immunohistochemistry. Our results suggest that W-mediated alterations of axonal membranes leads to an activation of Jun transcription factor within affected neurones despite an increase in neurotrophic NGF within their innervation area.

引用

页码：1322 / 1324

页数：3

共 20 条

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