FACTOR-VIII-C RELATIONSHIPS TO SELECTED LIPIDS, AGE, AND GENDER IN HEALTHY-ADULTS

The relationships between cholesterol, high-density lipoprotein-cholesterol (HDLC-C), age, gender, estrogen use, and coagulation factor VIII (VIII:C) were examined in a group (n = 230) of healthy adults, age 21 to 68. No relationships were noted between factor VIII:C and cholesterol or estrogen usage; Factor VIII:C and age were positively related. A significant negative correlation was found between factor VIII:C and HDL-C in the group after the adjustment of age and gender. The study suggests possible relationship of VIII:C to development of arterial disease during the aging process.