TISSUE PLASMINOGEN-ACTIVATOR TREATMENT OF EXPERIMENTAL SUBRETINAL HEMORRHAGE

被引:102
作者
LEWIS, H
RESNICK, SC
FLANNERY, JG
STRAATSMA, BR
机构
[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT OPHTHALMOL,LOS ANGELES,CA 90024
[2] UNIV CALIF LOS ANGELES,SCH MED,JULES STEIN EYE INST,LOS ANGELES,CA 90024
关键词
D O I
10.1016/S0002-9394(14)72259-7
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
To determine if tissue plasminogen activator, a clot-specific fibrinolytic agent, could eventually be used to assist in the clearance or removal of subretinal hemorrhage, we studied the effect of subretinal injections of tissue plasminogen activator, autologous blood, balanced salt solution, and the combination of either tissue plasminogen activator or balanced salt solution after subretinal injection of autologous blood on retinal morphologic characteristics and clearance of subretinal hemorrhage in the albino rabbit. No morphologic evidence of tissue plasminogen activator toxicity was found in the rabbit retina at a dose of 25 to 50-mu-g/0.1 ml. Subretinal hemorrhage cleared faster after subretinal injection of tissue plasminogen activator when compared to balanced salt solution (P = .0005) but did not completely prevent overlying retinal degeneration. Both tissue plasminogen activator and balanced salt solution were found to decrease the toxic effects of subretinal blood on the morphologic characteristics of the rabbit retina, and this effect can be explained at least partly by dilution of the subretinal blood.
引用
收藏
页码:197 / 204
页数:8
相关论文
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