PYRROLIZIDINE OXIMES - A NOVEL NEW CLASS OF DENDROBATID ALKALOIDS

被引:11
作者
TOKUYAMA, T [1 ]
DALY, JW [1 ]
GARRAFFO, HM [1 ]
SPANDE, TF [1 ]
机构
[1] NIDDKD,BETHESDA,MD 20892
关键词
D O I
10.1016/S0040-4020(01)80437-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Analysis of GC-FTIR spectra and reexamination of H-1- and C-13-NMR data led to revised structures for three closely related tricyclic alkaloids from a dendrobatid poison-frog Dendrobates pumilio. The simplest member, 222, is a spiropentano-pyrrolizidine oxime, while 236 is the corresponding O-methyl oxime and 252, a hydroxy-O-methyl oxime.
引用
收藏
页码:4247 / 4258
页数:12
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