CALCIUM-INDUCED ACETYLCHOLINE-RELEASE AND INTRAMEMBRANE PARTICLE OCCURRENCE IN PROTEOLIPOSOMES EQUIPPED WITH MEDIATOPHORE

被引：17

作者：

BROCHIER, G

GULIKKRZYWICKI, T

LESBATS, B

DEDIEU, JC

ISRAEL, M

机构：

[1] CNRS,DEPT NEUROCHIM,NEUROBIOL CELLULAIRE & MOLEC LAB,F-91198 GIF SUR YVETTE,FRANCE

[2] CNRS,CTR GENET MOLEC,F-91198 GIF SUR YVETTE,FRANCE

来源：

BIOLOGY OF THE CELL | 1992年 / 74卷 / 02期

关键词：

INTRAMEMBRANE PARTICLE; ACETYLCHOLINE RELEASE; MEDIATOPHORE; LIPOSOME;

D O I：

10.1016/0248-4900(92)90029-Z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proteoliposomes obtained from the mediatophore, a purified Torpedo electric organ nerve terminals protein, and endogenous lipids were used for a study of calcium-induced release of acetylcholine and freeze-fracture electron microscopy. Large intramembrane particles were induced by the influx of calcium into proteoliposomes, as previously observed for synaptosomes or stimulated electric organ nerve terminals. The involvement of mediatophore in a calcium dependent acetylcholine translocation seems therefore to be related to the occurrence of a category of intramembrane particles in the course of the release process.

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页码：225 / 230

页数：6

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