22-OXACALCITRIOL SUPPRESSES 25-HYDROXYCHOLECALCIFEROL-1-ALPHA-HYDROXYLASE IN RAT-KIDNEY

被引：16

作者：

GRIEFF, M

DUSSO, A

MORI, T

NISHII, Y

SLATOPOLSKY, E

BROWN, AJ

机构：

[1] WASHINGTON UNIV,SCH MED,DIV RENAL,ST LOUIS,MO 63110

[2] CHUGAI PHARMACEUT CO LTD,TOKYO 171,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 185卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80974-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

22-oxacalcitriol can decrease the serum level of 1,25-dihydroxycholecalciferol by increasing its metabolic clearance rate and decreasing its production rate. To determine whether 22-oxacalcitriol suppressed the renal 25-hydroxycholecalciferol-1α-hydroxylase we treated rats with 200 ng of 22-oxacalcitriol daily for 1 week. Enzyme activity was measured in vitro by measurement of production of 1,25-dihydroxycholecalciferol by renal slices incubated with 25-hydroxycholecalciferol. 22-oxacalcitriol significantly decreased the 25-hydroxycholecalciferol-1α-hydroxylase activity from 797 ± 208 pg of 1,25-dihydroxycholecalciferol/g of kidney/h in the control group to 257 ± 150 pg of 1,25-dihydroxycholecalciferol/g of kidney/h (p < 0.05). This is the first demonstration of suppression of the renal 25-hydroxycholecalciferol-1α-hydroxylase by the vitamin D3 analog, 22-oxacalcitriol. © 1992 Academic Press, Inc.

引用

页码：191 / 196

页数：6

共 16 条

[1] A NOVEL VITAMIN-D3 ANALOG, 22-OXA-1,25-DIHYDROXYVITAMIN-D3, INHIBITS THE GROWTH OF HUMAN BREAST-CANCER INVITRO AND INVIVO WITHOUT CAUSING HYPERCALCEMIA [J].