RIGHT-SIDED ENDOCARDITIS CAUSED BY STAPHYLOCOCCUS-AUREUS IN DRUG-ABUSERS

被引：42

作者：

FORTUN, J ^{[1
]}

PEREZMOLINA, JA ^{[1
]}

ANON, MT ^{[1
]}

MARTINEZBELTRAN, J ^{[1
]}

LOZA, E ^{[1
]}

GUERRERO, A ^{[1
]}

机构：

[1] HOSP RAMON Y CAJAL, DEPT MICROBIOL, E-28034 MADRID, SPAIN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 02期

关键词：

D O I：

10.1128/AAC.39.2.525

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A prospective, open, and randomized study of right-sided endocarditis caused by Staphylococcus aureus in drug abuse patients is reported, The following parenteral treatments were compared, Group A patients were treated with 2 g of cloxacillin every 4 h and 1.5 mg of gentamicin per kg of body weight every 8 h for 2 weeks, Group B patients were treated with teicoplanin at 10 mg/kg/12 h on the 1st to 3rd days, 6 mg/kg/12 h on the 4th to 7th days, and 7 mg/kg/24 h on the 8th to 28th days, Drug abusers with bacteremia caused by S. aureus and suggestive signs of endocarditis were included, Clinical failures were observed in one patient in group A and in four of six patients in group B, Three patients in group B developed breakthrough bacteremia with teicoplanin-susceptible strains on days +6, +14, and +19, Serum teicoplanin levels and serum bactericidal titers showed a decrease in the 2nd week, when dosages received were 7 mg/kg/day, In conclusion, in treatment of right-sided endocarditis caused by S. aureus in drug abusers with teicoplanin, the use of dosages of 7 mg/kg/day is not recommended even if patients have received dosages of 12 mg/kg/day during the 1st week.

引用

页码：525 / 528

页数：4