EMERGING PATTERNS OF HEART-DISEASE IN HIV-INFECTED HOMOSEXUAL SUBJECTS WITH AND WITHOUT OPPORTUNISTIC INFECTIONS - A PROSPECTIVE COLOR-FLOW DOPPLER-ECHOCARDIOGRAPHIC STUDY

We studied 124 homosexual men aged 36·7± 7·6 years (range 23-57) using Doppler echocardiography. One hundred and one patients (Group A) had had acquired immunodeficiency syndrome for 1·6 ± 1·0 years and 23 patients (Group B) had had HIV infection without opportunistic infections for 3·2 ± 2·3 years. Doppler echocardiography was normal in 31% of Group A patients and in 61% of Group B. Pericardial effusion was found in 44 Group A patients (44%) and two Group B patients (9%). In Group A, left ventricular dilatation and/or dysfunction were found in 20 patients (20%), aortic root dilatation and regurgitation in eight patients (8%) and an intracardiac echogenic mass in seven patients (7%); in Group B one patient (4%) had an intracardiac mass.Forty-four (44%) Group A patients had cardiac presentations, and of these 22 had cardiomegaly with clinical signs of heart failure, 10 patients had tachyarrhythmias compared to only two in Group B. Although the CD4 lymphocyte count (%) was significantly lower in Group A than in Group B (5·4 ± 6·1 vs 1·33 ± 7·3, P<0·001), the presence of pericardial effusion, left ventricular dysfunction, right-sided cardiac enlargement or the duration of HIV infection, did not relate to the CD4 level in either group.Although often not diagnosed clinically, cardiac involvement in patients with AIDS is a clinical reality, with pericardial effusion, cardiomyopathy and left ventricular dysfunction appearing to have a high prevalence in male homosexual patients with AIDS. These clinical and echocardiographic findings are associated with clinically apparent intercurrent opportunistic infections, rather than the HIV virus per se, or the severity of infection as reflected by the CD4 count. © 1994 The European Society of Cardiology.