AN IMPROVED METHOD OF OXAZOLIDINONE HYDROLYSIS IN THE ASYMMETRIC-SYNTHESIS OF ALPHA-ALKYLPROLINES

被引：18

作者：

GENIN, MJ ^{[1
]}

BAURES, PW ^{[1
]}

JOHNSON, RL ^{[1
]}

机构：

[1] UNIV MINNESOTA,DEPT MED CHEM,MINNEAPOLIS,MN 55455

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(00)73294-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improvement in Seebach's method for the synthesis of alpha-alkylprolines is reported wherein the hydrolysis of the chiral oxazolidinone 2 is performed on a suspension of silica gel in MeOH/H2O. Following hydrolysis, the pure alpha-alkylproline can he obtained by filtration thereby avoiding a tedious ion exchange purification.

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页码：4967 / 4968

页数：2

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