ADJUVANT EFFECT OF POLYADENYLIC POLYURIDYLIC ACID ON ANTIBODY-PRODUCTION OF RECOMBINANT HEPATITIS-B SURFACE-ANTIGEN IN MICE

被引：4

作者：

PARK, SJ

KIM, WH

HAN, KH

CHON, CY

HAHM, KB

MOON, YM

KANG, JK

PARK, IS

YOUN, JK

机构：

[1] AJOU UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,SUWON 442749,SOUTH KOREA

[2] YONSEI UNIV,COLL MED,DEPT INTERNAL MED,SEOUL 120749,SOUTH KOREA

[3] AJOU UNIV,SCH MED,DEPT GASTROENTEROL,SUWON 442749,SOUTH KOREA

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1995年 / 17卷 / 06期

关键词：

POLYADENYLIC POLYURIDYLIC ACID; ANTIBODY; HEPATITIS B ANTIGEN; MOUSE;

D O I：

10.1016/0192-0561(95)00031-V

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The adjuvant effect of polyadenylic.polyuridylic acid [poly(A).poly(U)] on antibody production against recombinant hepatitis B surface antigen (rHBsAg) was investigated. Immunization of adult Balb/c mice with rHBsAg plus poly(A).poly(U) elicited significantly higher antibody responses than immunization of mice immunized with rHBsAg alone. Such an adjuvant effect was evident even in mice sensitized with subimmunogenic doses of the antigen.

引用

页码：513 / 516

页数：4

共 20 条

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