AN EFFICIENT SYNTHESIS OF 3-TERT-AMINOPROPANOL DERIVATIVES BY REGIOSELECTIVE RING-OPENING OF TETRAHYDRO-1,3-OXAZINES WITH GRIGNARD-REAGENTS

被引：6

作者：

ALBEROLA, A ^{[1
]}

ALVAREZ, MA ^{[1
]}

ANDRES, C ^{[1
]}

GONZALEZ, A ^{[1
]}

PEDROSA, R ^{[1
]}

机构：

[1] UNIV VALLADOLID,FAC CIENCIAS,DEPT QUIM ORGAN,E-47011 VALLADOLID,SPAIN

来源：

SYNTHETIC COMMUNICATIONS | 1990年 / 20卷 / 08期

关键词：

D O I：

10.1080/00397919008052822

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Benzyl tetrahydro-1,3-oxazines react with methy1magnesium iodide, benzylmagnesium bromide,allylmagnesium chloride and phenylmagnesium bromide affording 3-tert-aminopropanol derivatives with excellent yields. By contrast, the same substrates do no react with sodium phenylacetilide or butyllithium, and the corresponding tetrahydro-1,3-oxazinium methiodides are also inert toward Grignard reagents. Copyright © 1990 by Taylor & Francis Group. All rights reserved.

引用

页码：1149 / 1158

页数：10

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