2-STAGE RELEASE OF BENZOCAINE FROM SUNFLOWER OIL GELATIN EMULSION FILMS

被引：5

作者：

MHANDO, JR ^{[1
]}

PO, ALW ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST,CTR MED BIOL,SCH PHARM,DRUG DELIVERY RES GRP,97 LISBURN RD,BELFAST BT9 7BL,ANTRIM,NORTH IRELAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 59卷 / 02期

关键词：

Benzocaine; Benzocaine emulsion-gel film; Controlled-release system; Sustained release system;

D O I：

10.1016/0378-5173(90)90091-H

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The release of benzocaine from thin emulsion-gel films is studied. It is shown that release of benzocaine from such films is complex possibly due to interaction between the drug and formaldehyde, the hardening agent. Reversible cross-linking of formaldehyde with gelatin may also be involved. With storage in a formaldehyde environment, a decrease in the apparent diffusion coefficient of benzocaine in the hardened films was observed. The release behaviour observed, with an initial burst, may be useful for designing systems with an immediate release dose. Stability of such systems will, however, need to be validated. © 1990.

引用

页码：165 / 170

页数：6

共 18 条

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