N-METHYL-N'-NITRO-N-NITROSOGUANIDINE - THE EFFECT ON MIGRATION AND CGMP LEVEL OF NEUTROPHILS

被引:7
作者
ELFERINK, JGR
DEKOSTER, BM
机构
[1] Department of Medical Biochemistry, University of Leiden, 2300 RA Leiden
关键词
NEUTROPHILS; CHEMOTAXIS; CHEMOKINESIS; CGMP; N-METHYL-N'-NITRO-N-NITROSOGUANIDINE;
D O I
10.1016/0300-483X(92)90169-F
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) causes a concentration-dependent increase of the cGMP level in rabbit peritoneal neutrophils. MNNG has a strong chemokinetic effect on neutrophils. In addition the compound also possesses a moderate chemotactic effect. The potentiating effect of MNNG on neutrophil migration is completely inhibited by pertussis toxin. The results support the view that in neutrophils cGMP is involved in chemokinesis and chemotaxis and that the cGMP-mediated potentiation of migration is controlled by a pertussis toxin-sensitive G-protein.
引用
收藏
页码:45 / 52
页数:8
相关论文
共 22 条
[1]  
AXELSSON KL, 1989, Z KARDIOL, V78, P11
[2]  
BENDTZEN K, 1977, ACTA PATH MICRO IM C, V85, P78
[5]   DIVERSE BIOLOGICAL ACTIONS OF ATRIAL-NATRIURETIC-PEPTIDE [J].
BRENNER, BM ;
BALLERMANN, BJ ;
GUNNING, ME ;
ZEIDEL, ML .
PHYSIOLOGICAL REVIEWS, 1990, 70 (03) :665-699
[6]  
COFFEY RG, 1988, J IMMUNOL, V140, P2695
[7]   CALCIUM-INDEPENDENT MODULATION OF CYCLIC-GMP AND ACTIVATION OF GUANYLATE CYCLASE BY NITROSAMINES [J].
DERUBERTIS, FR ;
CRAVEN, PA .
SCIENCE, 1976, 193 (4256) :897-899
[8]   THE EFFECT OF QUIN2 ON CHEMOTAXIS BY POLYMORPHONUCLEAR LEUKOCYTES [J].
ELFERINK, JGR ;
DEIERKAUF, M .
BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 846 (03) :364-369
[9]  
ELFERINK JGR, BIOCHEM PHARMACOL, V42, P1745
[10]  
ELFERINK JGR, IN PRESS IMMUNOPHARM