ANTI-AIDS AGENTS .4. TRIPTERIFORDIN, A NOVEL ANTI-HIV PRINCIPLE FROM TRIPTERYGIUM-WILFORDII - ISOLATION AND STRUCTURAL ELUCIDATION

被引：69

作者：

CHEN, K

SHI, Q

FUJIOKA, T

ZHANG, DC

HU, CQ

JIN, JQ

KILKUSKIE, RE

LEE, KH

机构：

[1] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

[2] SHANGHAI MED UNIV,SCH PHARM,DEPT CHEM NAT DRUGS,SHANGHAI 200032,PEOPLES R CHINA

[3] CAMBRIDGE BIOTECH CO,ROCKVILLE,MD 20850

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 01期

关键词：

D O I：

10.1021/np50079a013

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new kaurane-type diterpene lactone, tripterifordin [1], has been isolated from the roots of Tripterygium wilfordii. The structure of 1 was elucidated by spectroscopic methods, including the concerted application of a number of 2D nmr techniques that involved the H-1-H-1 COSY, heteronucleus-detected variants of the heteronuclear chemical shift correlation (HETCOR), phase-sensitive NOESY, and long-range HETCOR. Compound 1 shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 1-mu-g/ml.

引用

页码：88 / 92

页数：5

共 5 条

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