GASTROINTESTINAL TRANSIT OF A MATRIX TABLET FORMULATION - COMPARISON OF CANINE AND HUMAN DATA

Controlled release devices, based on high molecular weight hydrophilic polymers, have been shown in studies in dogs to have extended gastric retentive properties. However, the transit characteristics of the formulation in man were very similar to those reported previously for other single unit matrix systems. The results highlight the dramatic differences that can occur between animal models and human subjects and consequently data on gastrointestinal transit obtained in animal models should be interpreted with considerable caution.