MURINE CAGE DENSITY - CAGE AMMONIA LEVELS DURING THE REPRODUCTIVE-PERFORMANCE OF AN INBRED STRAIN AND 2 OUTBRED STOCKS OF MONOGAMOUS BREEDING PAIRS OF MICE

被引:15
作者
EVELEIGH, JR
机构
[1] AFRC Institute for Animal Health, Pirbright Laboratory, Surrey GU24 0NF, Ash Road, Pirbright, Woking
关键词
MURINE; CAGE DENSITY; AMMONIA; REPRODUCTION;
D O I
10.1258/002367793780810432
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 [兽医学];
摘要
The Laboratory Animial Breeders Association guidelines recommend a minimum floor area of 300 cm2 for a monogamous pair of inbred/outbred mice or a trio of inbreds. The mean level of ammonia produced during lactation from BALB/c, TO and CD-1 breeding pairs housed in M2 cages with a floor area of 300 cm2 on Day 4 after cleaning was 30 ppm, 87 ppm and 92 ppm, respectively. All 3 strains of mice, particularly the outbred strains, were subjected to high levels of ammonia as compared with human long-term health and safety occupational exposure limits (25 ppm). However, there is a gradient of ammonia within an M2 breeding cage from the nest (19 ppm), to the food hopper, 77 ppm. By ho using CD-1 pairs of mice in RM2 cages which have more than double the floor area of M2 cages (676 cm2), the mean level of ammonia during lactation on Day 4 after cleaning was reduced to 26 ppm. The reproductive performance on inbred/outbred strains of mice has to be equated with cage size (floor area) to maintain acceptable levels of ammonia. It is suggested that the recommended minimum floor areas for breeding mice be reviewed.
引用
收藏
页码:156 / 160
页数:5
相关论文
共 6 条
[1]
Donnelly H., 1989, Laboratory Animal Welfare Research: Rodents. Proceedings of a symposium organized by the Universities Federation for Animal Welfare, held at Royal Holloway and Bedford New College, University of London, Egham, Surrey, UK, 22 April, 1988., P17
[2]
EVELEIGH JR, 1991, J EXP ANIM SCI, V34, P236
[3]
EVELEIGH JR, 1992, ANIMAL TECHNOLOGY, V43, P37
[4]
GAMBLE M R, 1976, Laboratory Animals (London), V10, P93, DOI 10.1258/002367776781071477
[5]
1991, GUIDELINES CARE HOUS
[6]
1991, EH4089 HLTH SAF EX G