COMPARISON OF PLASMA PCR AND BRONCHOALVEOLAR LAVAGE FLUID CULTURE FOR DETECTION OF CYTOMEGALOVIRUS-INFECTION IN ADULT BONE-MARROW TRANSPLANT RECIPIENTS

被引：36

作者：

ASPIN, MM

GALLEZHAWKINS, GM

GIUGNI, TD

TEGTMEIER, B

LANG, DJ

SCHMIDT, GM

FORMAN, SJ

ZAIA, JA

机构：

[1] CITY HOPE NATL MED CTR, DEPT INFECT DIS, DIV PEDIAT, DUARTE, CA 91010 USA

[2] CHILDRENS HOSP ORANGE CTY, DEPT INFECT DIS, ORANGE, CA 92668 USA

[3] CITY HOPE NATL MED CTR, DEPT HEMATOL & BONE MARROW TRANSPLANTAT, DUARTE, CA 91010 USA

[4] CITY HOPE NATL MED CTR, DIV CLIN PATHOL, DUARTE, CA 91010 USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1994年 / 32卷 / 09期

关键词：

D O I：

10.1128/JCM.32.9.2266-2269.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Plasma PCR for human cytomegalovirus (CMV) DNA was compared with bronchoalveolar lavage (BAL) fluid culture as an indicator for disseminated CMV infection. Thirteen (32.5%) of 40 consecutive bone marrow transplant (BMT) recipients were BAL fluid culture positive for CMV on day 35 post-BMT, and 9 (69%) of the 13 had positive plasma PCRs between days 28 and 49. Of the 27 with negative BAL fluid cultures, 2 (7%) had positive plasma PCRs (P < 0.0001). Plasma CMV DNA in BMT recipients is a useful clinical marker for serious infection.

引用

页码：2266 / 2269

页数：4

共 28 条

[1] PROPHYLACTIC USE OF GANCICLOVIR IN ALLOGENEIC BONE-MARROW TRANSPLANTATION - ABSENCE OF CLINICAL CYTOMEGALOVIRUS-INFECTION [J].