CONTROLLED DRUG DISSOLUTION BY RADIATION-INDUCED POLYMERIZATION IN THE PRESENCE OF DIMETHYLAMINOETHYL METHACRYLATE METHYL METHACRYLATE COPOLYMER OR METHACRYLIC ACID METHYL ACRYLATE COPOLYMER

被引：13

作者：

YOSHIDA, M ^{[1
]}

KUMAKURA, M ^{[1
]}

KAETSU, I ^{[1
]}

机构：

[1] JAPAN ATOM ENERGY RES INST,TAKASAKI RADIAT CHEM RES ESTAB,TAKASAKI,GUNMA,JAPAN

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 07期

关键词：

Copolymers—anionic and cationic; controlled‐release tablets; dissolution rate; various drugs; Dissolution rates—various drugs; tablets containing radiation‐induced polymers of glass‐forming monomers in the presence of cationic and anionic copolymers; Dosage forms—controlled‐release delivery devices; radiation‐induced polymerization of glass‐forming monomers; low temperature; in the presence of dimethylaminoethyl methacrylate‐methyl methacrylate or methacrylic acid‐methyl acrylate copolymers; for various drugs; dissolution rate from tablets; Tablets—drug dissolution rate; radiation‐induced polymerization of glass‐forming monomers in the presence of dimethylaminoethyl methacrylate‐methyl methacrylate or methacrylic acid‐methyl acrylate copolymers;

D O I：

10.1002/jps.2600680719

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Polymer‐containing tablet preparation was studied using radiation‐induced polymerization of glass‐forming monomers at low temperatures in the presence of dimethylaminoethyl methacrylate‐methyl methacrylate copolymer or methyl acrylate‐methacrylic acid copolymer. Drug dissolution from tablets was in the pH 3.0‐8.0 range. A copolymer contained in the tablets dissolved in the dissolution medium at a specific pH. Drug dissolution from tablets took place rapidly at pH > 6.0 in the presence of methyl acrylate‐methacrylic acid copolymer and at pH < 5.0 in the presence of dimethylaminoethyl methacrylate‐methyl methacrylate copolymer. The polymers had fibrous or capillary pore structures in contrast to the spherical pore structures formed in the presence of polyethylene glycol 600. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：860 / 862

页数：3

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