PLATELET-DERIVED GROWTH-FACTOR (PDGF) IN PLASMA OF BREAST-CANCER PATIENTS - CORRELATION WITH STAGE AND RATE OF PROGRESSION

被引：88

作者：

ARIAD, S

SEYMOUR, L

BEZWODA, WR

机构：

[1] UNIV WITWATERSRAND,SCH MED,DEPT MED,HEMATOL ONCOL UNIT,YORK RD,JOHANNESBURG 2193,SOUTH AFRICA

[2] JOHANNESBURG HOSP,JOHANNESBURG,SOUTH AFRICA

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1991年 / 20卷 / 01期

关键词：

PLATELET-DERIVED GROWTH FACTOR; PLASMA CONCENTRATIONS; IMMUNOASSAY; BREAST CANCER; PROGNOSIS; TUMOR PROGRESSION;

D O I：

10.1007/BF01833352

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Plasma levels of platelet-derived growth factor (PDGF) were measured in 58 female patients with breast canCer and in 9 normal female control subjects by means of a specific radioimmunoassay. Levels in normal control subjects were all below the lower limits of detection by the assay (1.56 fmol/100-mu-l plasma). Two of 17 (12%) patients with stage 2 breast cancer had detectable plasma levels. Among patients with Stage 4 breast cancer 13/41 (32%) had significantly elevated levels (> 2 times the lower limit of sensitivity of the assay). Patients with elevated PDGF levels had a significantly greater degree of metastatic involvement and significantly shorter survival. Apart from being a marker of aggressive high bulk breast cancer, PDGF may be involved in the acceleration of growth of some metastatic breast tumors.

引用

页码：11 / 17

页数：7

共 36 条

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