T-CELL RECEPTOR GAMMA-DELTA-EXPRESSION ON LYMPHOCYTE POPULATIONS OF BREAST-CANCER PATIENTS

被引：20

作者：

ALAM, SM ^{[1
]}

CLARK, JS ^{[1
]}

LEECH, V ^{[1
]}

WHITFORD, P ^{[1
]}

GEORGE, WD ^{[1
]}

CAMPBELL, AM ^{[1
]}

机构：

[1] WESTERN INFIRM & ASSOCIATED HOSP,DEPT SURG,GLASGOW G11 6NT,SCOTLAND

来源：

IMMUNOLOGY LETTERS | 1992年 / 31卷 / 03期

关键词：

T-CELL RECEPTOR; GAMMA-DELTA; BREAST CANCER; TUMOR INFILTRATING LYMPHOCYTES; HUMAN LYMPH NODE;

D O I：

10.1016/0165-2478(92)90127-A

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The quantitative distribution and phenotype of gamma/delta lymphocytes in the peripheral blood (PBL), tumour draining lymph node (LNL) and tumour infiltrating lymphocytes (TIL) from breast carcinoma patients were determined by one- and two-colour flow cytometry. The TCR-gamma/delta+ cells generally expressed the T cell lineage antigen CD3. The proportions of such cells were variable but generally small from all the three sources. Phenotypic analysis revealed that the CD8 marker was consistently and predominantly observed on gamma/delta+ CD3+ cells in the tumour infiltrate, whereas CD4 expression, while generally low, was noted on a significant percentage (median 10%) of LNL gamma/delta+ lymphocytes. In both PBL and LNL the predominant gamma/delta cell population was CD4- 8-.

引用

页码：279 / 284

页数：6

共 18 条

[1] FLOW CYTOMETRIC ANALYSIS OF CELL-SURFACE CARBOHYDRATES IN METASTATIC HUMAN BREAST-CANCER [J].

ALAM, SM ;

WHITFORD, P ;

CUSHLEY, W ;

GEORGE, WD ;

CAMPBELL, AM .

BRITISH JOURNAL OF CANCER, 1990, 62 (02) :238-242

[2] DISTINCT MOLECULAR-FORMS OF HUMAN T-CELL RECEPTOR GAMMA-DELTA DETECTED ON VIABLE T-CELLS BY A MONOCLONAL-ANTIBODY [J].

BORST, J ;

VANDONGEN, JJM ;

BOLHUIS, RLH ;

PETERS, PJ ;

HAFLER, DA ;

DEVRIES, E ;

VANDEGRIEND, RJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (05) :1625-1644

[3]

BUCY RP, 1988, J IMMUNOL, V141, P2200

[4] A NEW T-CELL RECEPTOR GENE LOCATED WITHIN THE ALPHA-LOCUS AND EXPRESSED EARLY IN T-CELL DIFFERENTIATION [J].

CHIEN, YH ;

IWASHIMA, M ;

KAPLAN, KB ;

ELLIOTT, JF ;

DAVIS, MM .

NATURE, 1987, 327 (6124) :677-682

[5]

ELLIOTT JF, 1988, NATURE, V331, P627

[6] EXPRESSION OF THE GAMMA-DELTA-T-CELL RECEPTOR ON INTESTINAL CD8+ INTRAEPITHELIAL LYMPHOCYTES [J].

GOODMAN, T ;

LEFRANCOIS, L .

NATURE, 1988, 333 (6176) :855-858

[7] INTRAEPITHELIAL T-CELLS OF THE TCR-GAMMA/DELTA+CD8- AND V-DELTA-1/J-DELTA-1+ PHENOTYPES ARE INCREASED IN CELIAC-DISEASE [J].

HALSTENSEN, TS ;

SCOTT, H ;

BRANDTZAEG, P .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1989, 30 (06) :665-672

[8]

INGHIRAMI G, 1990, AM J PATHOL, V136, P357

[9] HOMING OF A GAMMA-DELTA THYMOCYTE SUBSET WITH HOMOGENEOUS T-CELL RECEPTORS TO MUCOSAL EPITHELIA [J].

ITOHARA, S ;

FARR, AG ;

LAFAILLE, JJ ;

BONNEVILLE, M ;

TAKAGAKI, Y ;

HAAS, W ;

TONEGAWA, S .

NATURE, 1990, 343 (6260) :754-757

[10] FRONTIERS OF THE IMMUNE-SYSTEM [J].

JANEWAY, CA .

NATURE, 1988, 333 (6176) :804-806

← 1 2 →