HERPES-SIMPLEX VIRUS AND HUMAN PAPILLOMAVIRUS SITES CORRELATE WITH CHROMOSOMAL BREAKPOINTS IN HUMAN CERVICAL-CARCINOMA

被引：22

作者：

DEBRAEKELEER, M

SREEKANTAIAH, C

HAAS, O

机构：

[1] MEM SLOAN KETTERING CANC CTR, GENET & CANC CYTOGENET LAB, NEW YORK, NY USA

[2] ST ANNA CHILDRENS HOSP, CHILDRENS CANC RES INST, VIENNA, AUSTRIA

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 59卷 / 02期

关键词：

D O I：

10.1016/0165-4608(92)90207-O

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The distribution of 1,912 breakpoints observed in a series of 148 cervical cancers was analyzed. Fifty bands were shown to be nonrandomly involved in chromosome structural rearrangements, One hundred thirty-three breaks were noted in bands known to contain a human papillomavirus integration site, and 454 breaks were noted in bands containing a herpes simplex virus breakage site. We suggest that herpes simplex viruses and, possibly, papillomaviruses play an important role in the carcinogenesis and/or development of cytogenetic abnormalities in cervical cancers.

引用

页码：135 / 137

页数：3

共 40 条

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