PROMPT REMISSION OF POSTRENAL TRANSPLANT NEPHROTIC SYNDROME WITH HIGH-DOSE CYCLOSPORINE

被引：19

作者：

SRIVASTAVA, RN ^{[1
]}

KALIA, A ^{[1
]}

TRAVIS, LB ^{[1
]}

DIVEN, SC ^{[1
]}

GUGLIUZZA, KK ^{[1
]}

RAJARAMAN, S ^{[1
]}

机构：

[1] UNIV TEXAS,MED BRANCH,DEPT PEDIAT,GALVESTON,TX 77555

来源：

PEDIATRIC NEPHROLOGY | 1994年 / 8卷 / 01期

关键词：

RECURRENT NEPHROTIC SYNDROME; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; CYCLOSPORINE A; RENAL TRANSPLANTATION;

D O I：

10.1007/BF00868281

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A 2.8-year-old girl with focal segmental glomerulosclerosis had recurrence of nephrotic syndrome within 3 days of renal transplantation and the serum creatinine increased. Renal biopsy showed cellular rejection and also complete effacement of the epithelial cell foot processes. The rejection responded to methylprednisolone therapy but massive proteinuria persisted. An increase in the dose of cyclosporine A to 14 mg/kg per day was followed by immediate remission of the proteinuria. One month later, a second renal biopsy showed only focal fusion of foot processes. She remains free of proteinuria 2 years later. We propose that the higher dose of cyclosporine caused remission of the nephrotic syndrome.

引用

页码：94 / 95

页数：2

共 11 条

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