LIMITED APPLICATION OF MOMETASONE FUROATE ON THE FACE AND INTERTRIGINOUS AREAS - ANALYSIS OF SAFETY AND EFFICACY

Forty patients with moderate to severe psoriasis or atopic dermatitis were enrolled in a study to determine the safety and efficacy of mometasone furoate. Patients were instructed to apply mometasone furoate ointment 0.1% once daily for 2 weeks. Treatments were applied by the patients to an individual target area that was preselected for evaluation of change in disease signs and symptoms. Psoriatic lesions were graded by evaluating the extent of erythema, plaque thickness, scaling, and pruritus. In patients with atopic dermatitis, erythema, lichenification and pruritus were measured. Each of these parameters was assessed on a scale from 0 to 3: 0 = normal, 1 = mild, 2 = moderate, 3 = severe. Half values were permitted. Evaluations of treated areas were made upon entry into the study and at days 2, 3, 4, 8, and 15. Examinations for signs of skin atrophy and telangiectasia were also made at each visit. Copyright © 1993, Wiley Blackwell. All rights reserved