DELTA-9-TETRAHYDROCANNABINOL REGULATES SUBSTANCE-P AND ENKEPHALIN MESSENGER-RNAS LEVELS IN THE CAUDATE-PUTAMEN

被引:21
作者
MAILLEUX, P
VANDERHAEGHEN, JJ
机构
[1] Unité de Recherche sur le Cerveau, Faculté de Médecine, Université Libre de Bruxelles, Bruxelles
来源
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1994年 / 267卷 / 01期
关键词
CANNABIS; CANNABINOID; MARIJUANA;
D O I
10.1016/0922-4106(94)90234-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
We have recently localized delta-9-tetrahydrocannabinol (THC) receptor in the projecting neurons of the striatum which are known to express the neuropeptides substance P and enkephalin. We now report for the first time, by quantitative in situ hybridization, that a 3-week treatment with THC significantly increases in the adult rat caudate-putamen the messenger RNAs levels for substance P and enkephalin. These data indicate that THC may regulate gene expression of neuropeptides in the brain.
引用
收藏
页码:R1 / R3
页数:3
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