DELTA-9-TETRAHYDROCANNABINOL REGULATES SUBSTANCE-P AND ENKEPHALIN MESSENGER-RNAS LEVELS IN THE CAUDATE-PUTAMEN

被引：21

作者：

MAILLEUX, P

VANDERHAEGHEN, JJ

机构：

[1] Unité de Recherche sur le Cerveau, Faculté de Médecine, Université Libre de Bruxelles, Bruxelles

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1994年 / 267卷 / 01期

关键词：

CANNABIS; CANNABINOID; MARIJUANA;

D O I：

10.1016/0922-4106(94)90234-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have recently localized delta-9-tetrahydrocannabinol (THC) receptor in the projecting neurons of the striatum which are known to express the neuropeptides substance P and enkephalin. We now report for the first time, by quantitative in situ hybridization, that a 3-week treatment with THC significantly increases in the adult rat caudate-putamen the messenger RNAs levels for substance P and enkephalin. These data indicate that THC may regulate gene expression of neuropeptides in the brain.

引用

页码：R1 / R3

页数：3

共 7 条

[1]

DEWEY WL, 1986, PHARMACOL REV, V38, P151

[2] D1 AND D2 DOPAMINE RECEPTOR REGULATED GENE-EXPRESSION OF STRIATONIGRAL AND STRIATOPALLIDAL NEURONS [J].