TRANSIENT ACCUMULATION OF NEW CLASS-II MHC MOLECULES IN A NOVEL ENDOCYTIC COMPARTMENT IN B-LYMPHOCYTES

被引：410

作者：

AMIGORENA, S ^{[1
]}

DRAKE, JR ^{[1
]}

WEBSTER, P ^{[1
]}

MELLMAN, I ^{[1
]}

机构：

[1] YALE UNIV, SCH MED, CTR CELL IMAGING, NEW HAVEN, CT 06520 USA

来源：

NATURE | 1994年 / 369卷 / 6476期

关键词：

D O I：

10.1038/369113a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Endocytosis of antigen by antigen-presenting cells results in the production of peptides that bind to newly synthesized class II molecules of the major histocompatibility complex. A new population of class II-enriched vesicles has been discovered in B lymphocytes that accumulate internalized antigen but are distinct from endosomes and lysosomes. These vesicles also transiently accumulate newly synthesized class II and class II-peptide complexes and appear to be a compartment specialized for the transport and loading of class II molecules.

引用

页码：113 / 120

页数：8

共 38 条

[1] CYTOPLASMIC DOMAIN HETEROGENEITY AND FUNCTIONS OF IGG FC-RECEPTORS IN LYMPHOCYTES-B
AMIGORENA, S
BONNEROT, C
DRAKE, JR
CHOQUET, D
HUNZIKER, W
GUILLET, JG
WEBSTER, P
SAUTES, C
MELLMAN, I
FRIDMAN, WH
[J]. SCIENCE, 1992, 256 (5065) : 1808 - 1812
[2] SELECTIVE STORAGE OF ACETYLCHOLINE, BUT NOT CATECHOLAMINES, IN NEUROENDOCRINE SYNAPTIC-LIKE MICROVESICLES OF EARLY ENDOSOMAL ORIGIN
BAUERFEIND, R
REGNIERVIGOUROUX, A
FLATMARK, T
HUTTNER, WB
[J]. NEURON, 1993, 11 (01) : 105 - 121
[3] BLAKE O, 1990, CELL, V63, P707
[4] BRAUNSTEIN NS, 1990, J IMMUNOL, V145, P1635
[5] SPECIFICITY AND PROMISCUITY AMONG NATURALLY PROCESSED PEPTIDES BOUND TO HLA-DR ALLELES
CHICZ, RM
URBAN, RG
GORGA, JC
VIGNALI, DAA
LANE, WS
STROMINGER, JL
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (01) : 27 - 47
[6] INTRACELLULAR CLASS-II HLA ANTIGENS ARE ACCESSIBLE TO TRANSFERRIN NEURAMINIDASE CONJUGATES INTERNALIZED BY RECEPTOR-MEDIATED ENDOCYTOSIS
CRESSWELL, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (23) : 8188 - 8192
[7] PROCESSED ANTIGEN BINDS TO NEWLY SYNTHESIZED MHC CLASS II MOLECULES IN ANTIGEN-SPECIFIC LYMPHOCYTES-B
DAVIDSON, HW
REID, PA
LANZAVECCHIA, A
WATTS, C
[J]. CELL, 1991, 67 (01) : 105 - 116
[8] FUCHS R, 1989, J BIOL CHEM, V264, P2212
[9] MHC CLASS-II STRUCTURE, OCCUPANCY AND SURFACE EXPRESSION DETERMINED BY POST-ENDOPLASMIC RETICULUM ANTIGEN-BINDING
GERMAIN, RN
HENDRIX, LR
[J]. NATURE, 1991, 353 (6340) : 134 - 139
[10] THE BIOCHEMISTRY AND CELL BIOLOGY OF ANTIGEN PROCESSING AND PRESENTATION
GERMAIN, RN
MARGULIES, DH
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1993, 11 : 403 - 450

← 1 2 3 4 →