Transcriptional regulation by cAMP

被引：82

作者：

Lee, Kevin A. W. ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Clare Hall Labs, Potters Bar EN6 3LD, Herts, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 1991年 / 3卷 / 06期

关键词：

D O I：

10.1016/0955-0674(91)90113-D

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cyclic AMP regulates a myriad of cellular processes through the cAMP-dependent protein kinase A. In many cases, activation of protein kinase A leads to altered patterns of gene transcription. Identification of the cAMP-response-element-binding-protein as a major nuclear substrate for protein kinase A accounts for many recent advances in understanding the signal transduction pathway. This review will focus on the role of cAMP-response-element-binding protein in coupling protein kinase A to the transcriptional machinery and the mechanisms that control cAMP signalling during mammalian development.

引用

页码：953 / 959

页数：7

共 41 条

[1] FLUORESCENCE RATIO IMAGING OF CYCLIC-AMP IN SINGLE CELLS [J].

ADAMS, SR ;

HAROOTUNIAN, AT ;

BUECHLER, YJ ;

TAYLOR, SS ;

TSIEN, RY .

NATURE, 1991, 349 (6311) :694-697

[2] NEGATIVE REGULATION BY GLUCOCORTICOIDS THROUGH INTERFERENCE WITH A CAMP RESPONSIVE ENHANCER [J].

AKERBLOM, IE ;

SLATER, EP ;

BEATO, M ;

BAXTER, JD ;

MELLON, PL .

SCIENCE, 1988, 241 (4863) :350-353

[3] 2 DISTINCT FORMS OF ACTIVE TRANSCRIPTION FACTOR CREB (CAMP RESPONSE ELEMENT BINDING-PROTEIN) [J].

BERKOWITZ, LA ;

GILMAN, MZ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5258-5262

[4] THE TISSUE-SPECIFIC EXTINGUISHER LOCUS TSE1 ENCODES A REGULATORY SUBUNIT OF CAMP-DEPENDENT PROTEIN-KINASE [J].

BOSHART, M ;

WEIH, F ;

NICHOLS, M ;

SCHUTZ, G .

CELL, 1991, 66 (05) :849-859

[5] A CYCLIC-AMP RESPONSE ELEMENT MEDIATES REPRESSION OF TYROSINE AMINOTRANSFERASE GENE-TRANSCRIPTION BY THE TISSUE-SPECIFIC EXTINGUISHER LOCUS TSE-1 [J].

BOSHART, M ;

WEIH, F ;

SCHMIDT, A ;

FOURNIER, REK ;

SCHUTZ, G .

CELL, 1990, 61 (05) :905-916

[6] PITUITARY HYPERPLASIA AND GIGANTISM IN MICE CAUSED BY A CHOLERA-TOXIN TRANSGENE [J].

BURTON, FH ;

HASEL, KW ;

BLOOM, FE ;

SUTCLIFFE, JG .

NATURE, 1991, 350 (6313) :74-77

[7] FUNCTION OF THE HOMEODOMAIN PROTEIN GHF1 IN PITUITARY CELL-PROLIFERATION [J].

CASTRILLO, JL ;

THEILL, LE ;

KARIN, M .

SCIENCE, 1991, 253 (5016) :197-199

[8] CAMP RESPONSE ELEMENT-BINDING PROTEIN IS ACTIVATED BY CA2+/CALMODULIN-DEPENDENT AS WELL AS CAMP-DEPENDENT PROTEIN-KINASE [J].

DASH, PK ;

KARL, KA ;

COLICOS, MA ;

PRYWES, R ;

KANDEL, ER .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (11) :5061-5065

[9]

DEUTSCH PJ, 1988, J BIOL CHEM, V263, P18466

[10] CREM GENE - USE OF ALTERNATIVE DNA-BINDING DOMAINS GENERATES MULTIPLE ANTAGONISTS OF CAMP-INDUCED TRANSCRIPTION [J].

FOULKES, NS ;

BORRELLI, E ;

SASSONECORSI, P .

CELL, 1991, 64 (04) :739-749

← 1 2 3 4 5 →