INFLUENCE OF CARRIER MOISTURE ADSORPTION CAPACITY ON THE DEGREE OF ADHESION OF INTERACTIVE MIXTURES

被引：13

作者：

PADMADISASTRA, Y ^{[1
]}

KENNEDY, RA ^{[1
]}

STEWART, PJ ^{[1
]}

机构：

[1] UNIV QUEENSLAND,DEPT PHARM,BRISBANE,QLD 4072,AUSTRALIA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 104卷 / 01期

关键词：

INTERACTIVE MIXING; PARTICLE ADHESION; CAPILLARY INTERACTION; SOLID BRIDGING; CRYSTAL BRIDGE;

D O I：

10.1016/0378-5173(94)90341-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The interaction of sulphathiazole and succinylsulphathiazole with Compactrol(R), TabBase(R), Emdex(R) and lactose granules was studied. Carriers with a high capacity to adsorb moisture caused a significant increase in the adhesion when the mixtures were stored under high humidity conditions. The effect was attributed to capillary interaction following liquid bridge formation between the drug and carrier surfaces. Oven drying of the moist mixtures further increased the degree of adhesion probably due to solid bridge formation.

引用

页码：R1 / R4

页数：4

共 12 条

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