BIOSYNTHESES OF NOVEL EMYCINS FROM THE MUTANT STRAIN STREPTOMYCES-CELLULOSAE SSP GRISEOINCARNATUS-1114-2

被引：32

作者：

GERLITZ, M ^{[1
]}

UDVARNOKI, G ^{[1
]}

ROHR, J ^{[1
]}

机构：

[1] UNIV GOTTINGEN,INST ORGAN CHEM,D-37077 GOTTINGEN,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 15期

关键词：

ANTIBIOTICS; BIOSYNTHESIS; OXIDOREDUCTASES; POLYKETIDES; REARRANGEMENTS;

D O I：

10.1002/anie.199516171

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Natural products such as 1 with unprecedented molecular frameworks are produced by the mutant 1114‐2 of Streptomyces cellulosae ssp. griseoincarnatus (FH‐S 1114). Biosynthetic investigations on this genetically modified strain show that the changes at the molecular level are caused mainly by the influence of an oxygenase. Moreover, an unusual rearrangement is also involved in the generation of the product palette. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：1617 / 1621

页数：5

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