INTRATUMORAL INJECTION OF AN ADENOVIRUS EXPRESSING INTERLEUKIN-2 INDUCES REGRESSION AND IMMUNITY IN A MURINE BREAST-CANCER MODEL

被引：165

作者：

ADDISON, CL

BRACIAK, T

RALSTON, R

MULLER, WJ

GAULDIE, J

GRAHAM, FL

机构：

[1] MCMASTER UNIV,DEPT BIOL,HAMILTON,ON L8S 4K1,CANADA

[2] MCMASTER UNIV,DEPT PATHOL,HAMILTON,ON L8S 4K1,CANADA

[3] CHIRON CORP,EMERYVILLE,CA 94608

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 18期

关键词：

D O I：

10.1073/pnas.92.18.8522

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rodent tumor cells engineered to secrete cytokines such as interleukin 2 (IL-2) or IL-4 are rejected by syngeneic recipients due to an enhanced antitumor host immune response. An adenovirus vector (AdCAIL-2) containing the human IL-2 gene has been constructed and shown to direct secretion of high levels of human IL-2 in infected tumor cells. AdCAIL-2 induces regression of tumors in a transgenic mouse model of mammary adenocarcinoma following intratumoral injection. Elimination of existing tumors in this way results in immunity against a second challenge with tumor cells. These findings suggest that adenovirus vectors expressing cytokines may form the basis for highly effective immunotherapies of human cancers.

引用

页码：8522 / 8526

页数：5

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